https://www.kerilab.org/home daily 1.0 2026-01-08 https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/8f3b670f-e876-409b-8c6a-903d56c1034e/Keri+Lab+Logo+no+background.png Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/d5be9159-418c-49bb-b4ca-debd4dc2a264/IMG-2020.jpg Home - Our Team We are very proud of our present and past lab members. Currently, the Keri lab is composed of graduate students, post-doctoral fellows and research assistants. We also have the pleasure of training students from the CWRU Postbaccalaureate Research Education Program (PREP), the Department of Pharmacology’s Summer Undergraduate Research Program (SURP), and the Young Scientist Foundation (YSF). Previous lab members hold various positions nationwide in academia, such as post-doctoral fellowships and tenured faculty positions, as well as in industry, including serving as medical science liasions and research scientists. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/530f2e75-bff7-4680-926b-360e71d6580a/CR+2024+Cover+Pic.jpg Home - Our Research The Keri lab has a wide range of focuses within the field of breast cancer. Our current projects include studying the role of genomic instability and the importance of epigenetic regulation in breast cancer, as well as identifying combination therapies that improve drug efficacy and elucidating mechanisms of therapeutic resistance in the hopes of preventing or countering such resistance. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/af3a2dd7-e5e6-43af-9665-3fb06f9bd415/UMAP+BC+ribbon.png Home - Our Publications The Keri lab has a record of publishing research in high-impact peer-reviewed journals. Click the button below to see the 5 most recent publications from our lab. The National Center for Biotechnology Information contains an up-to-date list of all of our publications. https://www.kerilab.org/transcription-and-epigenetics daily 0.75 2020-09-17 https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1599976436813-PIN2K8ILT2UW226W01QE/transcription-keri.jpg Transcription & Epigenetics https://www.kerilab.org/development daily 0.75 2020-09-17 https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1599975850929-QVL2BV6XCQV4T9JUHAXD/mammary-keri.jpg Mammary Gland Development https://www.kerilab.org/alumni daily 0.75 2026-03-03 https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/252c50ee-a5d4-4d4a-9f3a-4b92a7c17726/1772151566187.jfif https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/cf0174d5-c36c-4160-91e6-9b29037f1049/Natasha+Bio+Pic.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/f6d3bdcf-7947-41d3-8f4e-14a99ca3f5cd/Jessica.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/9d3b1bd5-bc76-4fdf-afa1-c7fac1ebd3db/Mitch.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/35fdb369-c988-4c40-ad54-6df2791ef993/Leslie.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/494fc2ce-1476-4a13-ab89-d474d737aaec/Katrina.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/3ce9dbf5-67e6-4401-b89e-8fefcd9964ab/Benjamin.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/0bfb7ca6-7a0d-4c2a-af74-fced5410b288/Lindsey.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1659106212170-HCKINNKZNBPPD7MQS0TL/Bryan.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607533614759-DCD7SD6QFJYQ0F79VQ9X/Elyse.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607533598970-VOUK8YUXARXU6WGS41O4/Amy.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607533630525-CSAR477KAB5ZRRIALIOH/Melyssa.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/493f0ba3-89f3-4a83-9974-62bbf7e713c0/Sylvia+Shabaya+Gayle.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/2bdf6169-7172-4c5e-9277-c3ccf6d3ae42/Jen+Hoffmann.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607534025430-Z5YAQ67S9RYCQKTS3806/Jennifer+Brancato+Sahni.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607534708939-JEC0OPT523ZPHIX8C9WL/Victoria+Osorio.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607534774242-U5QYT4TQQ2AAMVRL4W2W/Nicole+Restrepo.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607534854215-TKPBDJIZO1C1VXKVY4DN/Myrielis+Rivera.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607534926585-MSKSLLJLGKWE9WE3TW29/Garrett+Dunlap.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/6927343e-6502-4379-b78a-89456d73dd24/Jennifer+Yori.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607535183171-55EM5RZX3EC8FVNR0P6D/Erika+Ramos.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607535265313-XYWP5STR8V6STUCP1395/Gina+Bernardo.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607535807639-IJXY9ZVOS1HQMFY95T4D/Valery+Adorno-Cruz.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607535463885-FUGMAW8LADHQWTT1EWAK/Steve+Sizemore.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607535536925-XISBEB772K0ZTUFDV35H/Emhonta+Johnson.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/65190bfa-eea8-4eb4-93ec-742aff54c4dc/Marjorie.jfif https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607535674106-GW2EZCIB7UNCI5WQCVPY/Carlos.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607535972958-5MS495LY8JA7EI2SJGC2/Jonathan+Mosley.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607536130757-Y2GKCCOVI4UM1ZCM1JL6/Erin+Miliken.jpg https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1607536064914-1QIZ6YY0J9763MUHSAZ5/Melissa+Landis.jpg https://www.kerilab.org/news-and-events daily 0.75 2026-03-03 https://www.kerilab.org/signaling daily 0.75 2020-09-17 https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1599976142603-JEQ5FWWEJUK6AN4IO9GM/signaling-keri.jpg Signaling https://www.kerilab.org/publications daily 0.75 2025-06-12 https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/6508be99-7adc-4815-8d43-544e55054446/LIS1+H2AX.png Publications - The neural stem cell gene PAFAH1B1 controls cell cycle progression, DNA integrity, and paclitaxel sensitivity of triple-negative breast cancer cells Majmudar PR & Keri RA. J Biol Chem. 2025 May 14. doi: 10.1016/j.jbc.2025.110235 https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/4dd2d3a6-031a-495c-9014-887828668aa0/NEK2.jpg Publications - Targeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability Bobbitt JR, Cuellar-Vite L, Weber Bonk KL, Yancey MR, Majmudar PR, Keri RA. J Biol Chem. 2025 Jan 16. doi: 10.1016/j.jbc.2025.108196. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/7620fce4-63e8-433e-997f-c1b0945c6848/Multipolar+Spindle+YES1.png Publications - Targeting YES1 disrupts mitotic fidelity and potentiates the response to taxanes in triple-negative breast cancer Piemonte KM, Ingles NN, Weber Bonk KL, Valentine MJ, Majmudar PR, Singh S, Keri RA. Cancer Research. 2024 Jul 22. doi: 10.1158/0008-5472.CAN-23-2558. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/0967633f-29c6-476a-879d-0609c9e95957/CDK7i.png Publications - Disruption of CDK7 signaling leads to catastrophic chromosomal instability coupled with a loss of condensin-mediated chromatin compaction Piemonte KM, Webb BM, Bobbitt JR, Majmudar PR, Cuellar-Vite L, Bryson BL, Latina NC, Seachrist DD, Keri RA. J Biol Chem. 2023 May 17. doi: 10.1016/j.jbc.2023.104834. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/6f75e91f-c647-497e-b047-8faa24b0145c/tle3.png Publications - TLE3 Sustains Luminal Breast Cancer Lineage Fidelity to Suppress Metastasis Anstine LJ, Majmudar PR, Aponte A, Singh S, Zhao R, Weber Bonk KL, Abdul-Karim FW, Valentine M, Seachrist DD, Grenell-Nickelson KE, Cuellar-Vite L, Sizemore GM, Sizemore ST, Webb BM, Thompson CL, Keri RA. 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https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1639667563768-96ZFNN0AVRWILVAEI2F1/20211210_131733.jpg Gallery - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1639667538358-BS4LKE3V6G6NXITW57AY/20211210_131614.jpg Gallery - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1639667491275-Z5H999K2FT4X2QLGY36F/20211210_131750.jpg Gallery - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1639667516795-96011FNWC4V1ZTPIPVYG/20211210_131621.jpg Gallery - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.kerilab.org/protocols daily 0.75 2021-09-14 https://www.kerilab.org/ruth-keri-phd daily 0.75 2024-09-04 https://images.squarespace-cdn.com/content/v1/5f5bcb89f401d13e25335a39/1613670627462-AURMHX6OT2LUXDDOKPXQ/Keri+Bio+Pic.png Ruth A. Keri, PhD